Rat Anti-Mouse CD24/HSA-LE/AF Antibody MBS673598 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD24/HSA-LE/AF Antibody
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS673598
Quantity0.5 mg
ApplicationsFlow Cytometry, Immunoprecipitation
Conjugate/TagUnconjugated
FormatLow Endotoxin, Azide - Free (LE/AF)
ReactivityMouse
TargetCD24/HSA
IsotypeIgG2c kappa
Clone30-F1
HostRat
ImmunogenMouse CD24/heat stable antigen (HSA)
CD24 is expressed in B cells until their terminal differentiation into plasma cells.1 It has been used widely as a marker to fractionate different B-lineage differentiation stages.10 CD24 has been found on a variety of other hematopoietic and neural cell types, and is now classified as a costimulatory molecule.2-4 The CD24/HSA molecule is composed mostly of carbohydrate, with a protein core of only 31-35 amino acids in the human and 27 amino acids in the mouse.1, 3 The molecular mass is variable, ranging from 38-70 kDa.3 CD24 is now included in the large group of phosphatidylinositol-anchored membrane proteins.1-4 Studies with purified CD24 applied to latex beads have demonstrated a self-binding property, suggesting that the molecule is capable of promoting homotypic aggregation, binding and cell adhesion.3 This is supported by earlier observations of the blockade of B cell lymphoblast aggregation with anti- CD24 monoclonal antibody.6 Recent studies of murine CD24 have assigned a role for CD24/HSA as a ligand for P-selectin, a calcium-dependent lectin.7
ClonalityMonoclonal